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Open Access Green as soon as Postprint is submitted to ZB.
Das Design der Machbarkeitsstudien für eine bundesweite Kohortenstudie in Deutschland : Die Pretests der Nationalen Kohorten (NAKO).
The design of a nationwide cohort study in Germany : The pretest studies of the German National Cohort (GNC).
Bundesgesundheitsbl.-Gesund. 57, 1246-1254 (2014)
The German National Cohort (GNC) is the largest population-based cohort study in Germany. Beginning in 2014, a total of 200,000 women and men aged 20-69 years will be examined in 18 study centers. The aim of the study is to investigate the etiology of chronic diseases in relation to lifestyle, genetic, socioeconomic, and environmental factors and to develop appropriate methods for early diagnosis and prevention of diseases such as cardiovascular and respiratory diseases, cancer, diabetes, neurodegenerative/psychiatric diseases, as well as musculoskeletal and infectious diseases. Pretest studies (phase 1 and 2) were conducted to select methods, instruments, and procedures for the main study, to develop standard operating procedures, and to design and test the examination program according to acceptance, expected duration, and feasibility. The pretest studies included testing of interviews, questionnaires, anthropometric measurements, several medical examinations, and the collection of biosamples. In addition, the logistic, technical, and personnel infrastructure for the main study could be established including the study centers, the central infrastructure for data management, processes to coordinate the study, and data protection and quality management concepts. The examination program for the main phase of the GNC was designed and optimized based on the results of the pretest studies. The GNC is a population-based, highly standardized and excellently phenotyped cohort that will be the basis for new strategies for risk assessment and identification, early diagnosis, and prevention of multifactorial diseases.
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1.006
0.759
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12
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cohort Study ; Design ; Chronic Disease ; Pretest Study
Language
german
Publication Year
2014
HGF-reported in Year
2014
ISSN (print) / ISBN
1436-9990
e-ISSN
1437-1588
Quellenangaben
Volume: 57,
Issue: 11,
Pages: 1246-1254
Publisher
Springer
Publishing Place
New York
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-504000-007
PubMed ID
25293884
WOS ID
WOS:000344344900002
Scopus ID
84922099855
Erfassungsdatum
2014-10-13