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Möller, W. ; Schuschnig, U.* ; Meyer, G.* ; Mentzel, H.* ; Keller, M.*

Ventilation and drug delivery to the paranasal sinuses: Studies in a nasal cast using pulsating airflow.

Rhinology 46, 213-220 (2008)

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Open Access Green as soon as Postprint is submitted to ZB.

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Although there is a high incidence of nasal disorders including chronic sinusitis, there is limited success in the topical drug delivery to the nose and the paranasal sinuses. This is caused by the nose being an efficient filter for inhaled aerosol particles and the paranasal sinuses being virtually non ventilated. Method: The objective of this study was to visualize the efficiency of sinus ventilation in a nasal cast using dynamic 81mKr-gas imaging in combination with pulsating airflows. Furthermore, the efficiency of the deposition of radiolabelled aerosol was assessed. Results: Pulsation increased ventilation efficiency of the sinuses more than fivefold and aerosol deposition efficiency more than twentyfold, compared to delivery without pulsation. Furthermore pulsation increased aerosol deposition in the nasal airways by a factor of three. Using pulsating airflow Kr-gas ventilation and aerosol deposition efficiencies increased with increasing sinus volume. Pulsating airflow resulted in a deposition of up to 8% of the nebulized drug within the sinuses compared to 0.2% without pulsation. Conclusions: The study demonstrates the high efficiency of a pulsating airflow in paranasal sinus ventilation and aerosolized drug delivery. This proves that topical drug delivery to the paranasal sinuses in relevant quantities is possible.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords sinus ventilation; pulsating aerosol; krypton gas inhalation; scintigraphy; pari sinus

ISSN (print) / ISBN 0300-0729

e-ISSN 1996-8604

Journal Rhinology

Quellenangaben Volume: 46, Issue: 3, Pages: 213-220

Publisher International Rhinologic Society

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) CCG Inflammatory Lung Diseases (CPC-KEL)