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as soon as is submitted to ZB.
Securin is not required for chromosomal stability in human cells.
PLoS Biol. 3, 2127-2134:e416 (2005)
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest. Recently it has been reported that human cells without an hSecurin gene lose chromosomes at a high frequency. Here we show that, after hSecurin knockout through homologous recombination, chromosome losses are only a short, transient effect. After a few passages hSecurin(-/-) cells became chromosomally stable and executed mitoses normally. This was unexpected, as the securin loss resulted in a persisting reduction of the sister-separating protease separase and inefficient cleavage of the cohesin subunit Scc1. Our data demonstrate that securin is dispensable for chromosomal stability in human cells. We propose that human cells possess efficient mechanisms to compensate for the loss of genes involved in chromosome segregation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
SISTER-CHROMATID SEPARATION; ANAPHASE; COHESION; PHOSPHORYLATION; IDENTIFICATION; INHIBITION; METAPHASE; CLEAVAGE; YEAST; HPTTG
Language
english
Publication Year
2005
HGF-reported in Year
0
ISSN (print) / ISBN
1544-9173
e-ISSN
1545-7885
Journal
PLoS Biology
Quellenangaben
Volume: 3,
Issue: 12,
Pages: 2127-2134,
Article Number: e416
Publisher
Public Library of Science (PLoS)
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)
Research field(s)
Genetics and Epidemiology
PSP Element(s)
FE 70731
PubMed ID
16292982
WOS ID
WOS:000233903800008
Scopus ID
29144456625
Erfassungsdatum
2005-12-14