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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
The CALM and CALM/AF10 interactor CATS is a marker for proliferation.
Mol. Oncol. 2, 356-367 (2008)
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
CALM/AF10; Leukemia; Nucleolus; Proliferation; CATS
ISSN (print) / ISBN
1574-7891
e-ISSN
1878-0261
Journal
Molecular Oncology
Quellenangaben
Volume: 2,
Issue: 4,
Pages: 356-367
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed