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Fröhlich Archangelo, L. ; Greif, P.A. ; Hölzel, M. ; Harasim, T. ; Kremmer, E. ; Przemeck, G.K.H. ; Eick, D. ; Deshpande, A.J. ; Buske, C. ; Hrabě de Angelis, M. ; Saad, S.T.O. ; Bohlander, S.K.

The CALM and CALM/AF10 interactor CATS is a marker for proliferation.

Mol. Oncol. 2, 356-367 (2008)
DOI
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords CALM/AF10; Leukemia; Nucleolus; Proliferation; CATS
Language english
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 1574-7891
e-ISSN 1878-0261
Journal Molecular Oncology
Quellenangaben Volume: 2, Issue: 4, Pages: 356-367 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Reviewing status Peer reviewed
Institute(s) CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
Institute of Molecular Immunology (IMI)
Institute of Experimental Genetics (IEG)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease

30201 - Metabolic Health
Research field(s) Immune Response and Infection

Genetics and Epidemiology
PSP Element(s) G-521000-001
G-501700-003
G-500600-003
DOI 10.1016/j.molonc.2008.08.001
Scopus ID 56349104437
Erfassungsdatum 2008-12-08
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