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Wilkinson, P.* ; Sengerova, J.* ; Matteoni, R.* ; Chen, C-K.* ; Soulat, G.* ; Ureta-Vidal, A.* ; Fessele, S. ; Hagn, M. ; Massimi, M.* ; Pickford, K.* ; Butler, R.H.* ; Marschall, S. ; Mallon, A.-M.* ; Pickard, A.* ; Raspa, M.* ; Scavizzi, F.* ; Fray, M.* ; Larrigaldie, V.* ; Leyritz, J.* ; Birney, E.* ; Tocchini-Valentini, G.P.* ; Brown, S.* ; Herault, Y.* ; Montoliu, L.* ; Hrabě de Angelis, M. ; Smedley, D.*

EMMA - mouse mutant resources for the international scientific community.

Nucleic Acids Res. 38, D570-D576 (2010)
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The laboratory mouse is the premier animal model for studying human disease and thousands of mutants have been identified or produced, most recently through gene-specific mutagenesis approaches. High throughput strategies by the International Knockout Mouse Consortium (IKMC) are producing mutants for all protein coding genes. Generating a knock-out line involves huge monetary and time costs so capture of both the data describing each mutant alongside archiving of the line for distribution to future researchers is critical. The European Mouse Mutant Archive (EMMA) is a leading international network infrastructure for archiving and worldwide provision of mouse mutant strains. It operates in collaboration with the other members of the Federation of International Mouse Resources (FIMRe), EMMA being the European component. Additionally EMMA is one of four repositories involved in the IKMC, and therefore the current figure of 1700 archived lines will rise markedly. The EMMA database gathers and curates extensive data on each line and presents it through a user-friendly website. A BioMart interface allows advanced searching including integrated querying with other resources e.g. Ensembl. Other resources are able to display EMMA data by accessing our Distributed Annotation System server. EMMA database access is publicly available at http://www.emmanet.org.
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Publication type Article: Journal article
Document type Scientific Article
Keywords cryopreservation; mouse mutants; disease models; mouse repository; BIOLOGICAL DATA; BIOMART; SYSTEM
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Journal Nucleic Acids Research
Quellenangaben Volume: 38, Issue: Database Issue, Pages: D570-D576 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500600-003
PubMed ID 19783817
DOI 10.1093/nar/gkp799
WOS ID 000276399100092
Scopus ID 75549087684
Erfassungsdatum 2010-03-22
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