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Wei, J.* ; Blum, S. ; Jarmy, G.* ; Lamparter, M. ; Geishauser, A. ; Vlastos, G.A. ; Chan, G.* ; Fischer, K.-D. ; Rattat, D.* ; Debatin, K.-M.* ; Hatzopoulos, A.K.

Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastasis after intravenous delivery.

Cancer Cell 5, 477-488 (2004)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We show that mouse embryonic endothelial progenitor cells (eEPCs) home preferentially to hypoxic lung metastases when administered intravenously. This specificity is inversely related to the degree of perfusion and vascular density in the metastasis and directly related to local levels of hypoxia and VEGF. Ex vivo expanded eEPCs that were genetically modified with a suicide gene specifically and efficiently eradicated lung metastases with scant patent blood vessels. eEPCs do not express MHC I proteins, are resistant to natural killer cell-mediated cytolysis, and can contribute to tumor vessel formation also in nonsyngeneic mice. These results indicate that eEPCs can be used in an allogeneic setting to treat hypoxic metastases that are known to be resistant to conventional therapeutic regimes.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1535-6108
e-ISSN 1878-3686
Journal Cancer Cell
Quellenangaben Volume: 5, Issue: 5, Pages: 477-488 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Non-patent literature Publications
Reviewing status Peer reviewed