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Open Access Green as soon as Postprint is submitted to ZB.
Chronic radiation damage in the rectum of the rat after protracted fractionated irradiation.
Radiother. Oncol. 7, 155-163 (1986)
In this experiment, a protracted fractionation regime (18 fractions/170 days, dose/fraction: 6,7,8 Gy) caused late rectal obstruction in rats independently of any clinically detectable acute damage. Rectal obstruction was due to an ulcer which developed secondary to an atrophic mucosa and capillary damage. In agreement with our earlier protracted fractionation schedules, the results were not fitted well by the linear-quadratic model. However, there are indications of relatively low alpha/beta values. Hydronephroses and hydroureters were the only competing risks to rectal obstruction and they occurred independently of it.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0167-8140
e-ISSN
1879-0887
Journal
Radiotherapy and Oncology
Quellenangaben
Volume: 7,
Issue: 2,
Pages: 155-163
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik