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Open Access Green as soon as Postprint is submitted to ZB.
Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man.
Hum. Genet. 34, 137-142 (1976)
The family of an individual was studied who lacks the seventh component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygousdeficient. In this investigation, the following parameters were determined: complement components in functional and immunochemical tests; HLA-A,B antigens, HLA-D (MLC) determinants; the Bf system; glyoxalase I and B cell antigens. No evidence for linkage between the immunogenetic linkage group on chromosome 6 and gene(s) controlling the synthesis of the seventh component of complement was obtained. This is in accordance with the assumption that only genes controlling components of the initiating rather than the membrane attack unit of complement are linked to the HLA region.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
1976
HGF-reported in Year
0
ISSN (print) / ISBN
0340-6717
e-ISSN
1432-1203
Journal
Human Genetics
Quellenangaben
Volume: 34,
Issue: 2,
Pages: 137-142
Publisher
Springer
Reviewing status
Peer reviewed
Scopus ID
0017190687
Erfassungsdatum
1976-10-28