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Ziegler, W.H. ; Birkenfeld, P. ; Trott, K.R.*

The effect of combined treatment of HeLa cells with actinomycin D and radiation upon survival and recovery from radiation damage.

Radiother. Oncol. 10, 141-148 (1987)

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Open Access Green as soon as Postprint is submitted to ZB.

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The presence of actinomycin D during irradiation of HeLa cells leads to radiosensitization under aerobic but not under hypoxic conditions. Depending on the time interval between incubation with the drug and irradiation, pre- or post-treatment with actinomycin D also increases the radiosensitivity of HeLa cells irradiated in air. Pretreatment with actinomycin D does not inhibit recovery from potentially lethal radiation damage. In split-dose experiments, recovery from sublethal radiation damage was not impaired by the drug if present during the entire fractionation interval or if it was given as a short exposure after the first radiation dose.

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