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Open Access Green as soon as Postprint is submitted to ZB.
The effect of combined treatment of HeLa cells with actinomycin D and radiation upon survival and recovery from radiation damage.
Radiother. Oncol. 10, 141-148 (1987)
The presence of actinomycin D during irradiation of HeLa cells leads to radiosensitization under aerobic but not under hypoxic conditions. Depending on the time interval between incubation with the drug and irradiation, pre- or post-treatment with actinomycin D also increases the radiosensitivity of HeLa cells irradiated in air. Pretreatment with actinomycin D does not inhibit recovery from potentially lethal radiation damage. In split-dose experiments, recovery from sublethal radiation damage was not impaired by the drug if present during the entire fractionation interval or if it was given as a short exposure after the first radiation dose.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Actinomycin D-radiation Interactions ; Hela Cell ; Potentially Lethal Damage Repair ; Split-dose Recovery
ISSN (print) / ISBN
0167-8140
e-ISSN
1879-0887
Journal
Radiotherapy and Oncology
Quellenangaben
Volume: 10,
Issue: 2,
Pages: 141-148
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik