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Rozman, T.A. ; Rozman, K.K. ; Smith, G.S.

Relationship of body weight to disposition of hexachlorobenzene in rats.

Toxicol. Lett. 18, 171-175 (1983)
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Open Access Green as soon as Postprint is submitted to ZB.
Male rats of various body weights were dosed twice with [14C]hexachlorobenzene (50 mg/kg, p.o.) in olive oil by gavage on 2 consecutive days. During 2 weeks after dosage, cumulative excretion into urine was about 1% of the dose and unrelated to body weight. Cumulative excretion into feces was 30 ± 10% of the dose and decreased with increasing body weight. In contrast, the concentration of hexachlorobenzene in urine, feces, kidney, liver and adipose tissue 14 days after dosing was higher in larger than in smaller animals. However, the relative concentration, i.e. the concentration of hexachlorobenzene in urine, feces or tissue divided by the concentration of hexachlorobenzene in adipose tissue, eliminated most of the variability among individual animals. This allows direct comparison of dispositional data of animals with greatly differing body burdens.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 1983
HGF-reported in Year 0
ISSN (print) / ISBN 0378-4274
e-ISSN 1879-3169
Journal Toxicology Letters
Quellenangaben Volume: 18, Issue: 1-2, Pages: 171-175 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)
Scopus ID 0020555346
Erfassungsdatum 1983-12-31
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