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Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus.
PLoS Biol. 6, 2465-2475:e272 (2008)
Newborn granule cells become functionally integrated into the synaptic circuitry of the adult dentate gyrus after a morphological and electrophysiological maturation process. The molecular mechanisms by which immature neurons and the neurites extending from them find their appropriate position and target area remain largely unknown. Here we show that single-cell-specific knockdown of cyclin-dependent kinase 5 (cdk5) activity in newborn cells using a retrovirus-based strategy leads to aberrant growth of dendritic processes, which is associated with an altered migration pattern of newborn cells. Even though spine formation and maturation are reduced in cdk5-deficient cells, aberrant dendrites form ectopic synapses onto hilar neurons. These observations identify cdk5 to be critically involved in the maturation and dendrite extension of newborn neurons in the course of adult neurogenesis. The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
NEWLY GENERATED NEURONS; ENHANCED SYNAPTIC PLASTICITY; SEIZURE-INDUCED NEUROGENESIS; CYCLIN-DEPENDENT KINASE-5; NEURAL STEM-CELLS; FUNCTIONAL-INTEGRATION; CEREBRAL-CORTEX; SLICE CULTURES; DENTATE GYRUS; BRAIN
ISSN (print) / ISBN
1544-9173
e-ISSN
1545-7885
Journal
PLoS Biology
Quellenangaben
Volume: 6,
Issue: 11,
Pages: 2465-2475,
Article Number: e272
Publisher
Public Library of Science (PLoS)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)