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A first-generation packaging cell line for Epstein-Barr virus-derived vectors.
Proc. Natl. Acad. Sci. U.S.A. 96, 5188-5193 (1999)
On the basis of the B lymphotropic Epstein-Barr virus (EBV), we have constructed a virus-free packaging cell line that allows encapsidation of plasmids into herpesvirus particles. This cell line harbors an EBV mutant whose packaging signals have been deleted. The gene vectors, which can encompass very large, contiguous pieces of foreign DNA, carry all cis-acting elements involved in amplification and encapsidation into virus-like particles as well as those essential for extrachromosomal maintenance in the recipient cell. Although this first-generation packaging cell line suffers from unwanted recombination between the helper virus genome and gene vector DNAs, this approach opens the way to delivery and stable maintenance of any transgene in human B cells.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
1999
HGF-reported in Year
1999
ISSN (print) / ISBN
0027-8424
e-ISSN
1091-6490
Quellenangaben
Volume: 96,
Issue: 9,
Pages: 5188-5193
Publisher
National Academy of Sciences
Reviewing status
Peer reviewed
WOS ID
000080130200083
Scopus ID
0033609148
PubMed ID
10220441
Erfassungsdatum
1999-04-30