PuSH - Publication Server of Helmholtz Zentrum München: Action of tetrodotoxin on the contractile responses of isolated guinea pig urinary bladder preparation to X irradiation and to electrical stimulation.

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Michailov, M.C.* ; Welscher, U.E. ; Wolffhardt, C.M.

Action of tetrodotoxin on the contractile responses of isolated guinea pig urinary bladder preparation to X irradiation and to electrical stimulation.

Radiat. Environ. Biophys. 11, 289-294 (1975)

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Tetrodotoxin (10-8 to 10-6 g/ml) blocked the contractile responses of isolated guinea pig urinary bladder preparation to electrical (25 and 100 Hz) neural but not to transmural stimulation and to X irradiation (50 kV, 20 kR/min, 20 kR). The irradiation had no influence on the bladder responses to electrical and hormonal (acetylcholine and histamine) stimulation. It is concluded that the X ray induced contraction is of myogenic origin and that it is possibly not related to the electromechanical coupling system.

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