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The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
Br. J. Cancer 54, 239-243 (1986)
Publ. Version/Full Text
DOI
PMC
Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerably as a function of drug exposure dose. These differences are related to differential cellular drug uptake.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0007-0920
e-ISSN
1532-1827
Journal
British Journal of Cancer BJC
Quellenangaben
Volume: 54,
Issue: 2,
Pages: 239-243
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Physikalisch-Technische Abteilung