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Open Access Green as soon as Postprint is submitted to ZB.
Early down-regulation of c-myc in dimethylsulfoxide-induced mouse erythroleukemia (MEL) cells is mediated at the P1/P2 promoters.
Oncogene 8, 1099-1102 (1993)
A block of RNA elongation in exon 1 of the murine c-myc gene has been described for normal mouse fibroblats, lymphoid and myeloid cell lines and mouse erythroleukemia (MEL) cells. MEL cells differentiate after induction with the chemical agent dimethylsulfoxide (DMSO). The rapid initial down-regulation of c-myc that occurs after treatment with DMSO has been explained by an increase in the block of RNA elongation within the 3′ part of c-myc exon 1. In contrast to these reports, we find that down-regulation of c-myc in DMSO-induced MEL cells occurs at the c-myc P1 and P2 promoters. The P1 promoter is repressed by inhibition of initiation, whereas transcription of P2 RNA is blocked by retention of RNA polymerase II at or close to the P2 promoter. The earlier described block of RNA elongation at a run of five thymidines in the 3′ part of c-myc exon 1 was not observed.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0950-9232
e-ISSN
0950-9232
Journal
Oncogene
Quellenangaben
Volume: 8,
Issue: 4,
Pages: 1099-1102
Publisher
Nature Publishing Group
Reviewing status
Peer reviewed