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Takenaka, S. ; Heilmann, P. ; Ruprecht, L. ; Heinzmann, U. ; Murray, A.B. ; Fürst, G.M. ; Heini, A. ; Heyder, J.

Long-term exposure of dogs to a sulphite aerosol: IV. Effects on extrapulmonary airway morphology.

J. Aerosol Sci. 21, S483-S486 (1990)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The extrapulmonary airways of 8 male beagle dogs were examined histopathologically after continuous exposure to a sulphite aerosol at a concentration of 1 mg/m3 for 290 days. Hyperplastic foci were observed in the respiratory region of the posterior nasal cavity. The changes were characterized by a thickened epithelial layer resulting from epithelial proliferation, by a loss of secretory material and by moderate mononuclear cell infiltration. In the larynx an increased number of non-ciliated cells, and slight mononuclear cell infiltration were found. Tracheal changes were limited to an increased number of non-ciliated cells in the membranous portion. TEM (transmission electron microscopy) showed the changes in the trachea to be caused by disorder in the development of ciliated cells. These findings suggest that sulphite aerosols have adverse effects on the extrapulmonary airways of beagle dogs.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Beagle Dog ; Chronic Effect ; Extrapulmonary Airway ; Morphology ; Respiratory System ; Sulphite Aerosol
ISSN (print) / ISBN 0021-8502
e-ISSN 1879-1964
Journal Journal of Aerosol Science
Quellenangaben Volume: 21, Issue: , Pages: S483-S486 Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)
Institut für Inhalationsbiologie