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Open Access Green as soon as Postprint is submitted to ZB.
Polychlorinated biphenyls modulate protooncogene expression in Chang liver cells.
FEBS Lett. 339, 185-188 (1994)
In Chang liver cells we studied the influence of polychlorinated biphenyls (PCB) on the expression of different protooncogenes. In cells incubated with medium supplemented with PCB we observed an early effect after 3 h on c-erbA and c-erbH RNA level. This reduction of RNA was due to a delayed transcriptional activation of the genes. The PCB congener 3,3',4,4',5-pentachlorobiphenyl (5-CB) in a 1,000-fold lower concentration influenced protooncogene expression in the same manner. In contrast c-raf RNA level increased transiently after 24 h. The fact that persistent chemicals like PCB interfere with protooncogene expression is particularly interesting in view of their tumor promoting activity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
C-erba ; C-erbb ; C-raf ; Pcb ; Protooncogene Expression ; Tumor Promoter
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Journal
FEBS Letters
Quellenangaben
Volume: 339,
Issue: 1-2,
Pages: 185-188
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed