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Open Access Green as soon as Postprint is submitted to ZB.
Dose response for heritable translocations induced by acrylamide in spermatids of mice.
Mutat. Res. -Fund. Mol. Mech. Mutag. 309, 285-291 (1994)
A heritable translocation test was carried out with acrylamide (AA) to obtain a dose-response relationship for induction of reciprocal translocations in late spermatids of the mouse. Male C3H/El mice were treated with single i.p. doses of 50 and 100 mg/kg of acrylamide and mated 7-16 days after treatment to untreated female 102/El mice. Translocation carriers among the F1 progeny were selected by a sequential procedure of fertility testing and cytogenetic analysis including G-band karyotyping to determine the chromosomes involved in the respective translocations. The translocation frequencies observed with 50 mg/kg and 100 mg/kg of AA were 0.6% and 2.7%, respectively. The historical control translocation frequency was 0.04%. Doubling dose estimates based on these and previous data are discussed.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Acrylamide ; Heritable Translocations ; Mouse Spermatids
ISSN (print) / ISBN
0027-5107
e-ISSN
1873-135X
Quellenangaben
Volume: 309,
Issue: 2,
Pages: 285-291
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Säugetiergenetik
Department for Medical Information Systems (MEDIS)
Department for Medical Information Systems (MEDIS)