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Adler, I.-D. ; Reitmeir, P. ; Schmöller, R. ; Schriever-Schwemmer, G.

Dose response for heritable translocations induced by acrylamide in spermatids of mice.

Mutat. Res. -Fund. Mol. Mech. Mutag. 309, 285-291 (1994)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
A heritable translocation test was carried out with acrylamide (AA) to obtain a dose-response relationship for induction of reciprocal translocations in late spermatids of the mouse. Male C3H/El mice were treated with single i.p. doses of 50 and 100 mg/kg of acrylamide and mated 7-16 days after treatment to untreated female 102/El mice. Translocation carriers among the F1 progeny were selected by a sequential procedure of fertility testing and cytogenetic analysis including G-band karyotyping to determine the chromosomes involved in the respective translocations. The translocation frequencies observed with 50 mg/kg and 100 mg/kg of AA were 0.6% and 2.7%, respectively. The historical control translocation frequency was 0.04%. Doubling dose estimates based on these and previous data are discussed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Acrylamide ; Heritable Translocations ; Mouse Spermatids
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Journal Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
Quellenangaben Volume: 309, Issue: 2, Pages: 285-291 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institut für Säugetiergenetik
Department for Medical Information Systems (MEDIS)