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Ege, M.J.* ; Herzum, I.* ; Büchele, G.* ; Krauss-Etschmann, S. ; Lauener, R.P.* ; Roponen, M.* ; Hyvärinen, A.* ; Vuitton, D.A.* ; Riedler, J.* ; Brunekreef, B.* ; Dalphin, J.-C.* ; Braun-Fahrländer, C.* ; Pekkanen, J.* ; Renz, H.* ; von Mutius, E.* ; PASTURE Study Group (*)

Prenatal exposure to a farm environment modifies atopic sensitization at birth.

J. Allergy Clin. Immunol. 122, 407-412 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Background: Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age. Objective: We sought to evaluate the effects of maternal exposure to animal sheds and other farm-related exposures during pregnancy on cord blood IgE levels in a prospective birth cohort. Methods: Pregnant women living in rural areas in Austria, Finland, France, Germany, and Switzerland were recruited in the third trimester of pregnancy. Information on maternal farm-related exposures, nutrition, and health during pregnancy was obtained by means of interviews. Specific IgE levels for food and common inhalant allergens were assessed in cord blood of 922 children and peripheral blood samples of their mothers. Results: Different sensitization patterns in cord blood of farm and nonfarm children were observed. In multivariable analysis consumption of boiled, but not unboiled, farm milk during pregnancy was positively associated with specific IgE to cow's milk independently from maternal IgE. In contrast, there was an inverse relationship between maternal exposure to animal sheds and cord blood IgE levels against seasonal allergens (adjusted odds ratio, 0.38; 95% CI, 0.21-0.70). This association was not confounded by maternal IgE levels. Maternal contact with hay enhanced the protective effect of exposure to animal sheds on IgE levels to grass pollen in cord blood.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords prenatal exposure; atopic sensitization; cord blood; farming; microbial components
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Journal The journal of allergy and clinical immunology
Quellenangaben Volume: 122, Issue: 2, Pages: 407-412 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CCG Immune Regulation in Childhood (IMI-KIK)