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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Metabolic evidence for biogeographic isolation of the extremophilic bacterium Salinibacter ruber.
ISME J. 2, 242-253 (2008)
The biogeography of prokaryotes and the effect of geographical barriers as evolutionary constraints are currently subjected to great debate. Some clear-cut evidence for geographic isolation has been obtained by genetic methods but, in many cases, the markers used are too coarse to reveal subtle biogeographical trends. Contrary to eukaryotic microorganisms, phenotypic evidence for allopatric segregation in prokaryotes has never been found. Here we present, for the first time, a metabolomic approach based on ultrahigh resolution mass spectrometry to reveal phenotypic biogeographical discrimination. We demonstrate that strains of the cosmopolitan extremophilic bacterium Salinibacter ruber, isolated from different sites in the world, can be distinguished by means of characteristic metabolites, and that these differences can be correlated to their geographical isolation site distances. The approach allows distinct degrees of discrimination for isolates at different geographical scales. In all cases, the discriminative metabolite patterns were quantitative rather than qualitative, which may be an indication of geographically distinct transcriptional or posttranscriptional regulations
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
biogeography; extremophilic bacteria; mass spectrometry; metabolomics; Salinibacter ruber
ISSN (print) / ISBN
1751-7362
e-ISSN
1751-7370
Journal
ISME Journal
Quellenangaben
Volume: 2,
Issue: 3,
Pages: 242-253
Publisher
Nature Publishing Group
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)