Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
Publ. Version/Full Text Volltext
DOI
PMC
 |
Open Access Gold |
as soon as is submitted to ZB.
Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.
Proc. Natl. Acad. Sci. U.S.A. 101, 15782-15787 (2004)
The interplay of environmental and genetic factors in the developmental organization of the hippocampus has not been fully elucidated. The neuropeptide corticotropin-releasing factor (CRF) is released from hippocampal interneurons by environmental signals, including stress, to increase synaptic efficacy. In the early postnatal hippocampus, we have previously characterized a transient population of CRF-expressing Cajal-Retzius-like cells. Here we queried whether this stress-activated neuromodulator influences connectivity in the developing hippocampal network. Using mice deficient in the principal hippocampal CRF receptor [CRF(1)(-/-)] and organotypic cultures grown in the presence of synthetic CRF, or CRF receptor antagonists, we found robust effects of CRF on dendritic differentiation in hippocampal neurons. In CRF(1)(-/-) mice, the dendritic trees of hippocampal principal cells were exuberant, an effect that was induced in normal hippocampi in vitro by the presence of CRF(1) antagonists. In both cases, total dendritic length and dendritic branching were significantly increased. In contrast, exogenous synthetic CRF blunted the dendritic growth in hippocampal organotypic cultures. Taken together, these findings suggest that endogenous CRF, if released excessively by previous early postnatal stress, might influence neuronal connectivity and thus function of the immature hippocampus.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Altmetric
10.272
0.000
135
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
corticotropin-releasing hormone; stress; corticotropin-releasing factor receptor; neuropeptide; cajal-retzius cells; CAJAL-RETZIUS CELLS; CENTRAL NERVOUS-SYSTEM; RAT-BRAIN; RECEPTOR ANTAGONIST; DENTATE GYRUS; IMMATURE RAT; ENTORHINAL FIBERS; NEURONAL-ACTIVITY; BINDING-PROTEIN; GRANULE CELLS
Language
english
Publication Year
2004
HGF-reported in Year
0
ISSN (print) / ISBN
0027-8424
e-ISSN
1091-6490
Quellenangaben
Volume: 101,
Issue: 44,
Pages: 15782-15787
Publisher
National Academy of Sciences
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-520600-001
PubMed ID
15496472
WOS ID
000224922300043
Erfassungsdatum
2004-12-17