PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Schneider, M.R.* ; Wolf, E.* ; Braun, J.* ; Kolb, H.-J. ; Adler, H.

Canine embryonic stem cells: State of the art.

Theriogenology 74, 492-497 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Embryonic stem cells (ESCs) are permanent cell lines that can be maintained in a pluripotent, undifferentiated state. Appropriate environmental stimuli can cause them to differentiate into cell types of all three germ layers both in vitro and in vivo. Embryonic stem cells bear many opportunities for clinical applications in tissue engineering and regenerative medicine. Whereas most of our knowledge on the biology and technology of ESCs is derived from studies with mouse cells, large animal models mimicking important aspects of human anatomy, physiology, and pathology more closely than mouse models are urgently needed for studies evaluating the safety and efficacy of cell therapies. The dog is an excellent model for studying human diseases, and the availability of canine ESCs would open new possibilities for this model in biomedical research. In addition, canine ESCs could be useful for the development of cell-based approaches for the treatment of dogs. Here, we discuss the features of recently reported canine embryo-derived cells and their potential applications in basic and translational biomedical research.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
2.073
1.600
9
13
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Canine; Differentiation; Dog; Embryonic stem cells; Pluripotent stem cells
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0093-691X
e-ISSN 1879-3231
Journal Theriogenology
Quellenangaben Volume: 74, Issue: 4, Pages: 492-497 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) CCG Hematopoetic Cell Transplants (IMI-KHZ)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-520300-001
PubMed ID 19963261
DOI 10.1016/j.theriogenology.2009.09.032
Scopus ID 77955512672
Erfassungsdatum 2010-10-07
[➜Report correction]