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Naf, a trans-regulating negative-acting factor encoded within the mouse mammary tumor virus open reading frame region.
J. Virol. 64, 6355-6359 (1990)
The mouse mammary tumor virus (MMTY) long terminal repeat (LTR) open reading frame (ORF) encodes a nagative acting factor (naf). In our test system, naf mediates its effect in trans on another MMTV provirus in which the 5′ LTM has been replaced by that of Rous sarcoma virus. naf effects are evidenced at the evidenced at the level of transcriptional initiation rather than as reduced mRNA stability. The introduction of a premature termination codon into the MMTV LTR-encoded ORF abolishes the transcriptional down regulation localizing naf within the ORF. In addition, sequences in the gag/pol genes between + 320 and + 646 and between + 3626 and + 4590 relative to the site of transcription initiation are also involved in the MMTV- mediated transcriptional down regulation.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
Publication Year
1990
HGF-reported in Year
1990
ISSN (print) / ISBN
0022-538X
e-ISSN
1098-5514
Journal
Journal of Virology
Quellenangaben
Volume: 64,
Issue: 12,
Pages: 6355-6359
Publisher
American Society for Microbiology (ASM)
Reviewing status
Peer reviewed
Scopus ID
0025245833
PubMed ID
2173798
Erfassungsdatum
1990-12-31