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Open Access Green as soon as Postprint is submitted to ZB.
A nonparametric method for the derivation of αbeta; ratios from the effect of fractionated irradiations.
Int. J. Radiat. Biol. 59, 1253-1268 (1991)
Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence. The analysis is employed to derive the αbeta; ratios of the linear-quadratic dose dependence, and different methods have been developed for this purpose. A common method uses the so-called Fe plot. A more complex but also more rigorous method has been introduced by Lam et al. (1979). Their method, which is based on numerical optimization procedures, is generalized and somewhat simplified in the present study. Tumour-regrowth data are used to explain the nonparametric procedure which provides αbeta; ratios without the need to postulate analytical expressions for the relationship between cell survival and regrowth delay.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0955-3002
e-ISSN
1362-3095
Quellenangaben
Volume: 59,
Issue: 5,
Pages: 1253-1268
Publisher
Informa Healthcare
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)