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Open Access Green as soon as Postprint is submitted to ZB.
Kinetics of recovery from sublethal radiation damage in four murine tumors.
Radiother. Oncol. 18, 79-88 (1990)
The kinetics of repair of sublethal radiation damage (SLD) was studied in four transplantable C3H mouse tumors, i.e. mammary carcinoma AT17, fibrosarcoma SSK2, and squamous cell carcinomas AT51 and AT478. Tumors were irradiated with 4 fractions of 300 kV X-rays given under local hypoxia at intervals ranging from 0 to 6 h. Radiation response was measured by growth delay, which was directly analyzed using a general curve description based on the extended linear-quadratic model (exponential repair kinetics). In contrast to existing methods all growth delay values were utilized to estimate the α/β ratios and the half-times as well as their confidence limits in a non-linear least squares analysis. The half-times were 42, 44, 54 and 31 min, respectively. It is concluded that repair of SLD is virtually complete after 5 h in these tumors. This is also due to the relatively small proportion of repairable damage in these tumors reflected in their α/β values, which were 38, 30, 54 and 42 Gy, respectively.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Direct Analysis ; Murine Tumors ; Sld Repair Kinetics ; Tumor Growth Delay
ISSN (print) / ISBN
0167-8140
e-ISSN
1879-0887
Journal
Radiotherapy and Oncology
Quellenangaben
Volume: 18,
Issue: 1,
Pages: 79-88
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)