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EBNA-2 in Transcription activation of viral and cellular.
In: Epstein-Barr Virus. Latency and Transformation. Norfolk: Caister Academic Press, 2010. 61-80
Epstein-Barr virus nuclear antigen-2 (EBNA-2) plays a key role in B-cell growth transformation by initiating and maintaining the proliferation of infected B-cells upon EBV infection in vitro. EBNA-2 is one of the first viral genes expressed after virus infection. By activating viral as well as cellular target genes EBNA-2 initiates the transcription of a cascade of primary and secondary target genes, which eventually govern the activation of the resting B-cell, cell cycle entry and proliferation of the growth transformed cells. The growth transformed B-cells exhibit a phenotype reminiscent of antigen activated B-cells. In addition, EBNA-2´s anti-apoptotic activities protect the infected B-cell. The multiple mechanisms by which EBNA-2 exerts its functions are reflected by the association of EBNA-2 with several cellular and viral proteins as well as a rapidly growing spectrum of activated cellular target genes. The finding that EBNA-2 and activated Notch signalling both converge on the cellular DNA binding and repressor protein CBF1 has raised the question, to which extent the functions of both proteins overlap.
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Publication type
Article: Edited volume or book chapter
Editors
Robertson, E.S.*
ISBN
978-1-904455-62-2
Book Volume Title
Epstein-Barr Virus. Latency and Transformation
Quellenangaben
Pages: 61-80
Publisher
Caister Academic Press
Publishing Place
Norfolk
Non-patent literature
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Institute(s)
Research Unit Gene Vector (AGV)