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Open Access Green as soon as Postprint is submitted to ZB.
Modelling urinary excretion of molybdenum after oral and intravenous administration of stable tracers.
Radiat. Prot. Dosim. 127, 136-139 (2007)
An extensive study using stable isotopes of molybdenum as tracers was undertaken to investigate intestinal uptake, systemic kinetics and urinary excretion of molybdenum in healthy human volunteers. In total 63 experiments with 17 volunteers were performed administering the tracers in different chemical forms and measuring their concentrations in blood plasma and urine samples by means of activation analysis and mass spectrometry. Molybdenum was eliminated very rapidly from the circulation. The amount eliminated via the renal pathway was observed to be dependent on several factors, such as form and modality of administration and also the total amount of circulating molybdenum. The fact that the urinary excretion patterns diverged significantly from the current predictions of the International Commission on Radiological Protection model might be relevant when using the model for retrospective intake assessments in case of an accident. On the basis of the experimental data, a more realistic compartmental structure has been presented.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
molybdenum; urinary
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Journal
Radiation Protection Dosimetry
Quellenangaben
Volume: 127,
Issue: 1-4,
Pages: 136-139
Publisher
Oxford University Press
Publishing Place
Oxford
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)