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Winkelmann, J. ; Polo, O.* ; Provini, F.* ; Nevsimalova, S.* ; Kemlink, D.* ; Sonka, K.* ; Högl, B.* ; Poewe, W.* ; Stiasny-Kolster, K.* ; Oertel, W.* ; de Weerd, A.* ; Strambi, L.F.* ; Zucconi, M.* ; Pramstaller, P.P.* ; Arnulf, I.* ; Trenkwalder, C.* ; Klein, C.* ; Hadjigeorgiou, G.M.* ; Happe, S.* ; Rye, D.* ; Montagna, P.*

Genetics of restless legs syndrome (RLS: State-of-the-art and future directions).

Mov. Disord. 22, (Suppl.18), 449-458 (2007)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords restless legs syndrome; genetics; sleep
ISSN (print) / ISBN 0885-3185
e-ISSN 1531-8257
Journal Movement Disorders
Quellenangaben Volume: 22, Issue: SUPPL. 18, Pages: 449-458, Article Number: , Supplement: (Suppl.18)
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)