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Open Access Green as soon as Postprint is submitted to ZB.
Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells.
Glia 55, 1061-1073 (2007)
Neurosteroids, such as progesterone, influence central nervous system development and function by regulating a broad spectrum of physiological processes. Here, we investigated membrane-initiated actions of progesterone in the retina and identified the membrane-associated progesterone receptor component 1 (PGRMC1). We found PGRMC1 expressed mainly in retinal Muller glia (RMG) and retinal pigment epithelium, and localized uniquely to microsomal and plasma membrane fractions. In RMG, membrane-impermeable progesterone conjugate induced calcium influx and subsequent phosphatidylinositol 3-kinase-mediated phosphorylation of PKC and ERK-1/2. Induction by progesterone also led to PKC-dependent activation of VEGF gene expression and protein synthesis, suggesting a contribution of membrane-initiated hormone effects to VEGF induced neovascularization within retina.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
neurosteroids; transmembrane receptor; intracellular calcium; retinal glial cells
ISSN (print) / ISBN
0894-1491
e-ISSN
1098-1136
Journal
Glia
Quellenangaben
Volume: 55,
Issue: 10,
Pages: 1061-1073
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed