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Aubele, M. ; Walch, A.K. ; Ludyga, N. ; Braselmann, H. ; Atkinson, M.J. ; Luber, B.* ; Auer, G.* ; Tapio, S. ; Cooke, T.* ; Bartlett, J.M.*

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.

Br. J. Cancer 99, 1089-1095 (2008)
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The cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis. Using immunohistochemistry, we performed a retrospective study on 426 archival breast cancer samples from patients with long-term follow-up and compared the protein expression levels of PTK6, the HER receptors, Sam68 (a substrate of PTK6), and signalling proteins including MAP kinase (MAPK), phosphorylated MAPK (P-MAPK), and PTEN. We show that PTK6 expression is of significant prognostic value in the outcome of breast carcinomas. In multivariate analysis, the disease-free survival of patients of >or=240 months was directly associated with the protein expression level of PTK6 (P
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Publication type Article: Journal article
Document type Scientific Article
Keywords PTK6 (BRK); breast cancer; prognosis; MAPK; Sam68; PTEN
Language english
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 0007-0920
e-ISSN 1532-1827
Journal British Journal of Cancer BJC
Quellenangaben Volume: 99, Issue: 7, Pages: 1089-1095 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)
Institute of Molecular Radiation Biology (IMS)
Institute of Radiation Biology (ISB)
Research Unit Analytical Pathology (AAP)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease

30202 - Environmental Health
30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies

Radiation Sciences
PSP Element(s) G-500300-001
G-500400-002
G-500200-001
G-500390-001
DOI 10.1038/sj.bjc.6604660
Scopus ID 53049087852
Erfassungsdatum 2008-12-08
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