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Open Access Green as soon as Postprint is submitted to ZB.
Early BCG and pertussis vaccination and atopic diseases in 5- to 7-year-old preschool children from Augsburg, Germany: Results from the MIRIAM study.
Pediatr. Allergy Immunol. 18, 5-9 (2007)
The role of immunization in the development of atopic disorders is still under debate. One reason might be, that because of high vaccination coverage in most countries only few and selected children are not immunized, leading to unstable and often biased effect estimates. In Germany, the situation was different between 1985 and 1991: bacillus Calmette-Guérin (BCG) and pertussis vaccination were not officially recommended leading to high numbers of non-vaccinated children in the 1990s. We report on a cross-sectional study with 1673 participants among 5- to 7-year-old preschool children conducted in 1996. We found no hint that BCG vaccination or whole-cell pertussis (WCP) vaccination may lead to higher prevalences of asthma, allergic rhinitis, eczema or allergic sensitization at preschool age. None of the associations was significantly positive. WCP vaccination may be protective against asthma OR 0.55 (95% CI: 0.31-0.98) and against symptoms of eczema in boys.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
preschool children; vaccination; bacillus Calmette-Guérin; pertussis; atopic; eczema; hay fever; asthma
ISSN (print) / ISBN
0905-6157
e-ISSN
1399-3038
Journal
Pediatric Allergy and Immunology
Quellenangaben
Volume: 18,
Issue: 1,
Pages: 5-9
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)