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Promotion of initiated cells by radiation-induced cell inactivation.

Radiat. Res. 170, 613-617 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Cells on the way to carcinogenesis can have a growth advantage relative to normal cells. It has been hypothesized that a radiation-induced growth advantage of these initiated cells might be induced by an increased cell replacement probability of initiated cells after inactivation of neighboring cells by radiation. Here Monte Carlo simulations extend this hypothesis for larger clones: The effective clonal expansion rate decreases with clone size. This effect is stronger for the two-dimensional than for the three-dimensional situation. The clones are irregular, far from a circular shape. An exposure-rate dependence of the effective clonal expansion rate could come in part from a minimal recovery time of the initiated cells for symmetric cell division.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2008
HGF-reported in Year 0
ISSN (print) / ISBN 0033-7587
e-ISSN 1938-5404
Quellenangaben Volume: 170, Issue: 5, Pages: 613-617 Article Number: , Supplement: ,
Publisher Radiation Research Society
Reviewing status Peer reviewed
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Radiation Sciences
PSP Element(s) G-501100-006
Erfassungsdatum 2008-12-08