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Open Access Green as soon as Postprint is submitted to ZB.
Promotion of initiated cells by radiation-induced cell inactivation.
Radiat. Res. 170, 613-617 (2008)
Cells on the way to carcinogenesis can have a growth advantage relative to normal cells. It has been hypothesized that a radiation-induced growth advantage of these initiated cells might be induced by an increased cell replacement probability of initiated cells after inactivation of neighboring cells by radiation. Here Monte Carlo simulations extend this hypothesis for larger clones: The effective clonal expansion rate decreases with clone size. This effect is stronger for the two-dimensional than for the three-dimensional situation. The clones are irregular, far from a circular shape. An exposure-rate dependence of the effective clonal expansion rate could come in part from a minimal recovery time of the initiated cells for symmetric cell division.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0033-7587
e-ISSN
1938-5404
Journal
Radiation Research
Quellenangaben
Volume: 170,
Issue: 5,
Pages: 613-617
Publisher
Radiation Research Society
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Protection (ISS)