PuSH - Publication Server of Helmholtz Zentrum München

Zeggini, E.* ; Scott, L.J.* ; Saxena, R.* ; Voight, B.F.* ; Marchini, J.L.* ; Hu, T.* ; de, Bakker, P.I.* ; Abecasis, G.R.* ; Almgren, P.* ; Andersen, G.* ; Ardlie, K.* ; Boström, K.B.* ; Bergman, R.N.* ; Bonnycastle, L.L.* ; Borch-Johnsen, K.* ; Burtt, N.P.* ; Chen, H.* ; Chines, P.S.* ; Daly, M.J.* ; Deodhar, P.* ; Ding, C.J.* ; Doney, A.S.* ; Duren, W.L.* ; Elliott, K.S.* ; Erdos, M.R.* ; Frayling, T.M.* ; Freathy, R.M.* ; Gianniny, L.* ; Grallert, H. ; Grarup, N.* ; Groves, C.J.* ; Guiducci, C.* ; Hansen, T.* ; Herder, C.* ; Hitman, G.A.* ; Hughes, T.E.* ; Isomaa, B.* ; Jackson, A.U.* ; Jørgensen, T.* ; Kong, A.* ; Kubalanza, K.* ; Kuruvilla, F.G.* ; Kuusisto, J.* ; Langenberg, C.* ; Lango, H.* ; Lauritzen, T.* ; Li, Y.* ; Lindgren, C.M.* ; Lyssenko, V.* ; Marvelle, A.F.* ; Meisinger, C. ; Midthjell, K.* ; Mohlke, K.L.* ; Morken, M.A.* ; Morris, A.D.* ; Narisu, N.* ; Nilsson, P.* ; Owen, K.R.* ; Palmer, C.N.* ; Payne, F.* ; Perry, J.R.* ; Pettersen, E.* ; Platou, C.* ; Prokopenko, I.* ; Qi, L.* ; Qin, L.* ; Rayner, N.W.* ; Rees, M.* ; Roix, J.J.* ; Sandbaek, A.* ; Shields, B.* ; Sjögren, M.* ; Steinthorsdottir, V.* ; Stringham, H.M.* ; Swift, A.J.* ; Thorleifsson, G.* ; Thorsteinsdottir, U.* ; Timpson, N.J.* ; Tuomi, T.* ; Tuomilehto, J.* ; Walker, M.* ; Watanabe, R.M.* ; Weedon, M.N.* ; Willer, C.J.* ; Wellcome Trust Case Consortium (WTCCC) (*) ; Illig, T. ; Hveem, K.* ; Hu, FB.* ; Laakso, M.* ; Stefansson, K.* ; Pedersen, O.* ; Wareham, N.J.* ; Barroso, I.* ; Hattersley, A.T.* ; Collins, FS.* ; Groop, L.* ; McCarthy, M.I.* ; Boehnke, M.* ; Altshuler, D.*

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Nat. Genet. 40, 638-645 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 40, Issue: 5, Pages: 638-645 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)