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Open Access Green as soon as Postprint is submitted to ZB.
Systemic inflammation, genetic susceptibility and lung function.
Eur. Respir. J. 32, 92-97 (2008)
Local inflammation in airway diseases is well recognised, but less is known about the association between low-grade systemic inflammatory processes and lung function. The aim of the present study was to assess the association between inflammatory markers and lung function, taking into account polymorphisms in genes coding for inflammatory markers. In 134 post-myocardial infarction patients, six repeated measurements of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen in peripheral blood were assayed using high-sensitivity tests. Spirometry was conducted at baseline. Genotyping of single nucleotide polymorphisms was performed in genes coding for the inflammatory markers. CRP and IL-6 levels were negatively associated with forced expiratory volume in one second (FEV(1)), forced vital capacity (FVC) and mean forced expiratory flow between 25 and 75% of FVC (FEF(25-75%)). In the CRP gene, both the polymorphism rs1205 and the haplotype 2 showed a protective association with FEV(1) and FEF(25-75%), and, to a lesser extent, with FVC. rs1205 and haplotype 2 were both negatively associated with CRP levels in peripheral blood. Analysis with instrumental variables also showed a protective effect between these CRP gene polymorphisms and lung function. Results are very suggestive that heritability of lung function is at least partly controlled by the CRP gene. Applying a Mendelian randomisation approach, the study supports a causal association between low-grade general inflammation and airway diseases.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
C-reactive protein; genes; lung function; Mendelian randomisation
Language
english
Publication Year
2008
HGF-reported in Year
2008
ISSN (print) / ISBN
0903-1936
e-ISSN
1399-3003
Journal
European Respiratory Journal
Quellenangaben
Volume: 32,
Issue: 1,
Pages: 92-97
Publisher
European Respiratory Society
Publishing Place
Sheffield
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
PSP Element(s)
G-503900-005
Scopus ID
52749091857
Erfassungsdatum
2008-10-13