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Depner, M.* ; Kormann, M.S.* ; Klopp, N. ; Illig, T. ; Vogelberg, C.* ; Weiland, S.K.* ; von Mutius, E.* ; Combadière, C.* ; Kabesch, M.*

CX3CR1 polymorphisms are associated with atopy but not asthma in German children.

Int. Arch. Allergy Immunol. 144, 91-94 (2007)
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Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates monocyte migration and macrophage differentiation as well as T cell-dependent inflammation. Two common, nonsynonymous polymorphisms in CX3CR1 have previously been shown to alter the function of the CX3CL1/CX3CR1 pathway and were suggested to modify the risk for asthma. Using matrix-assisted laser desorption/ionization time-of-flight technology, we genotyped polymorphisms Val249Ile and Thr280Met in a cross-sectional population of German children from Munich (n = 1,159) and Dresden (n = 1,940). For 249Ile an odds ratio of 0.77 (95% confidence interval 0.63-0.96; p = 0.017) and for 280Met an odds ratio of 0.71 (95% confidence interval 0.56-0.89; p = 0.004) were found with atopy in Dresden but not in Munich. Neither polymorphism was associated with asthma. Thus, amino acid changes in CX3CR1 may influence the development of atopy but not asthma in German children. Potentially, other factors such as environmental effects may modify the role of CX3CR1 polymorphisms.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Asthma; Atopy; Chemokine; Polymorphism; CX3CR1
Language english
Publication Year 2007
HGF-reported in Year 0
ISSN (print) / ISBN 1018-2438
e-ISSN 1423-0097
Journal International Archives of Allergy and Immunology
Quellenangaben Volume: 144, Issue: 1, Pages: 91-94 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; Bangalore ; Bangkok ; Singapore ; Tokyo ; Sydney
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-003
PubMed ID 17505143
DOI 10.1159/000102620
WOS ID 000248807700013
Scopus ID 34547741692
Erfassungsdatum 2007-12-31
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