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de Marco, R.* ; Accordini, S.* ; Cerveri, I.* ; Corsico, A.* ; Antò, J.M.* ; Künzli, N.* ; Janson, C.* ; Sunyer, J.* ; Jarvis, D.* ; Chinn, S.* ; Vermeire, P.* ; Svanes, C.* ; Ackermann-Liebrich, U.* ; Gislason, T.* ; Heinrich, J. ; Leynaert, B.* ; Neukirch, F.* ; Schouten, J.P.* ; Wjst, M. ; Burney, P.*

Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm.

Am. J. Respir. Crit. Care Med. 175, 32-39 (2007)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Rationale: The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results. Objectives: To assess the incidence of COPD in a cohort of young adults and to test whether chronic cough/phlegm and dyspnea are independent predictors of COPD. Methods: An international cohort of 5,002 subjects without asthma (ages 20–44 yr) with normal lung function (FEV1/FVC ratio >= 70%) from 12 countries was followed from 1991–2002 in the frame of the European Community Respiratory Health Survey II. Incident cases of COPD were those who had an FEV1/FVC ratio less than 70% at the end of the follow-up, but did not report having had a doctor diagnose asthma during the follow-up. Main Results: The incidence rate of COPD was 2.8 cases/1,000/yr (95% confidence interval [CI], 2.3–3.3). Chronic cough/phlegm was an independent and statistically significant predictor of COPD (incidence rate ratio [IRR], 1.85; 95% CI, 1.17–2.93) after adjusting for smoking habits and other potential confounders, whereas dyspnea was not associated with the disease (IRR = 0.98; 95% CI, 0.64–1.50). Subjects who reported chronic cough/phlegm both at baseline and at the follow-up had a nearly threefold-increased risk of developing COPD with respect to asymptomatic subjects (IRR = 2.88; 95% CI, 1.44–5.79). Conclusions: The incidence of COPD is substantial even in young adults. The presence of chronic cough/phlegm identifies a subgroup of subjects with a high risk of developing COPD, independently of smoking habits.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords chronic cough and phlegm; chronic obstructive pulmonary disease; incidence; epidemiology
ISSN (print) / ISBN 1073-449X
e-ISSN 1535-4970
Journal American Journal of Respiratory and Critical Care Medicine
Quellenangaben Volume: 175, Issue: 1, Pages: 32-39 Article Number: , Supplement: ,
Publisher American Thoracic Society
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Lung Health and Immunity (LHI)