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Role of hyperthermia in medical oncology.
Onkologe 16, 1063-1071 (2010)
The hallmarks of hyperthermia and its pleotropic effects are in favour of its combined use with chemotherapy. Preclinical research reveals that for heat killing and synergistic effects the thermal dose is most critical. Thermal enhancement of drug cytotoxicity is accompanied by cellular death and necrosis. Hereby, temperature application rate as well as sequence and time interval are important for both in vitro and in vivo thermal sensitizations of tumour cells. The positive results of phase II/III trials have definitely established hyperthermia in combination with chemotherapy as a novel clinical modality for the treatment of cancer. Hyperthermia targets the action of chemotherapy within the heated tumour. In specific clinical settings hyperthermia has proven its value and deserves a greater focus and investigation in other malignancies. To further define the role of hyperthermia in multimodal treatment, tumour patients should be included into randomized trials.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hyperthermia; Soft tissue sarcoma; Cervical cancer; Pancreatic cancer; Bladder cancer
Language
english
Publication Year
2010
HGF-reported in Year
2010
ISSN (print) / ISBN
0947-8965
e-ISSN
1433-0415
Journal
Onkologe, Der
Quellenangaben
Volume: 16,
Issue: 11,
Pages: 1063-1071
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-521100-001
Scopus ID
78751677591
Erfassungsdatum
2010-12-31