PuSH - Publication Server of Helmholtz Zentrum München

Mocikat, R. ; Kardinal, C. ; Klobeck, H.-G.*

Differential interactions between the immunoglobulin heavy chain mu intron and 3' enhancer.

Eur. J. Immunol. 25, 3195-3198 (1995)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The immunoglobulin heavy chain 3' enhancer may be a novel type of a transcriptional regulation element in as much as its function is position dependent. We show that there are interactions between the mu intron and 3' enhancer which are differentially regulated depending on the distance between the two elements. Thus, a transcriptional repression is exerted by the 3' enhancer when juxtaposed to the intron enhancer. Whereas no or only modest synergism between the immunoglobulin mu intron and 3' enhancer has been reported to date, we show here that the stimulatory effect is substantially increased by extending the distance between the two enhancers. In our stable expression system, the mu intron enhancer insulated the test gene from neighboring chromatin.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords Chimeric Antibody ; Enhancer ; Igh Locus ; Lymphoid Cell Line ; Transcriptional Regulation
ISSN (print) / ISBN 0014-2980
e-ISSN 1521-4141
Journal European Journal of Immunology
Quellenangaben Volume: 25, Issue: 11, Pages: 3195-3198 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Reviewing status Peer reviewed
Institute(s) AG Translationale Molekulare Immunologie (TMI)