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Open Access Green as soon as Postprint is submitted to ZB.
Differential interactions between the immunoglobulin heavy chain mu intron and 3' enhancer.
Eur. J. Immunol. 25, 3195-3198 (1995)
The immunoglobulin heavy chain 3' enhancer may be a novel type of a transcriptional regulation element in as much as its function is position dependent. We show that there are interactions between the mu intron and 3' enhancer which are differentially regulated depending on the distance between the two elements. Thus, a transcriptional repression is exerted by the 3' enhancer when juxtaposed to the intron enhancer. Whereas no or only modest synergism between the immunoglobulin mu intron and 3' enhancer has been reported to date, we show here that the stimulatory effect is substantially increased by extending the distance between the two enhancers. In our stable expression system, the mu intron enhancer insulated the test gene from neighboring chromatin.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chimeric Antibody ; Enhancer ; Igh Locus ; Lymphoid Cell Line ; Transcriptional Regulation
ISSN (print) / ISBN
0014-2980
e-ISSN
1521-4141
Journal
European Journal of Immunology
Quellenangaben
Volume: 25,
Issue: 11,
Pages: 3195-3198
Publisher
Wiley
Publishing Place
Hoboken
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
AG Translationale Molekulare Immunologie (TMI)