PuSH - Publication Server of Helmholtz Zentrum München: Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Perchermeier, M.M. ; Kiefer, F. ; Wiebel, F.J.

Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines.

Toxicol. Lett. 72, 53-57 (1994)

DOI

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H411EC3/G-, 5L and BWI-J, which are distinguished by their specific expression of xenobiotic metabolizing enzymes. The results show that polycyclic nitroarenes differentially affect the test cell lines suggesting that some compounds, such as 1,3-dinitropyrene, are activated by cytochrome P4501A1, others, such as 1,6-dinitropyrene, by reductase(s) and acetyltransferase. No such cell specific responses were seen for 13 monocyclic nitroarenes tested. This group of chemicals apparently is activated by an enzyme(s) other than the polycyclic nitroarenes tested.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Keywords Cell Lines ; Cytotoxicity ; Nitroaromatic Compounds

ISSN (print) / ISBN 0378-4274

e-ISSN 1879-3169

Journal Toxicology Letters

Quellenangaben Volume: 72, Issue: 1-3, Pages: 53-57

Publisher Elsevier

Publishing Place Amsterdam

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)