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Perchermeier, M.M. ; Kiefer, F. ; Wiebel, F.J.

Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines.

Toxicol. Lett. 72, 53-57 (1994)

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The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H411EC3/G-, 5L and BWI-J, which are distinguished by their specific expression of xenobiotic metabolizing enzymes. The results show that polycyclic nitroarenes differentially affect the test cell lines suggesting that some compounds, such as 1,3-dinitropyrene, are activated by cytochrome P4501A1, others, such as 1,6-dinitropyrene, by reductase(s) and acetyltransferase. No such cell specific responses were seen for 13 monocyclic nitroarenes tested. This group of chemicals apparently is activated by an enzyme(s) other than the polycyclic nitroarenes tested.

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