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Open Access Green as soon as Postprint is submitted to ZB.
Methods and application of time-resolved fluorescence microscopy.
Proc. SPIE 2083, 108-116 (1994)
The combination of fluorescence microscopy and time-resolved techniques opens up new possibilities in studying pharmacokinetics and localization of various drugs on a cellular scale. The fluorescence decay time of many molecules is modulated by the physical and chemical properties of the microenvironment, such as viscosity, polarity, pH-value, etc. The alternation of the decay time can also be used to pursue chemical transformations of a drug like degradation, monomerization, or protonation. This paper presents applications of this method from the field of photosensitizing dyes used in photodynamic therapy.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Journal
Proceedings of SPIE
Quellenangaben
Volume: 2083,
Pages: 108-116
Publisher
SPIE
Reviewing status
Peer reviewed
Institute(s)
Institute of Groundwater Ecology (IGOE)