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del Barco Barrantes, I.* ; Montero-Pedrazuela, A.* ; Guadano-Ferraz, A.* ; Obregon, M.J.* ; de Mena, R.M.* ; Gailus-Durner, V. ; Fuchs, H. ; Franz, T.J.* ; Kalaydjiev, S.* ; Klempt, M.* ; Hölter, S.M. ; Rathkolb, B.* ; Reinhard, C. ; de Escobar, G.M.* ; Bernal, J.* ; Busch, D.H.* ; Wurst, W. ; Wolf, E.* ; Schulz, S. ; Shtrom, S.* ; Greiner, E.* ; Hrabě de Angelis, M. ; Westphal, H.* ; Niehrs, C.*

Generation and characterization of dickkopf3 mutant mice.

Mol. Cell. Biol. 26, 2317-2326 (2006)
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dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Dkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels. Mutant mice are euthyroid, and the data do not support a relationship of dkk3 with thyroid hormone metabolism. Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0270-7306
e-ISSN 1098-5549
Journal Molecular and Cellular Biology
Quellenangaben Volume: 26, Issue: 6, Pages: 2317-2326 Article Number: , Supplement: ,
Publisher American Society for Microbiology (ASM)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
Lung Health and Immunity (LHI)