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Open Access Green as soon as Postprint is submitted to ZB.
Initiation of enzyme-altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay.
Carcinogenesis 14, 1229-1231 (1993)
Cyproterone acetate (CPA) is a synthetic steroid which is used in oral contraceptive and anti-androgen formulations. It has previously been classified as a tumor promoter in rat liver. Recent studies have shown that CPA induces DNA repair synthesis in isolated hepatocytes, and this implies that CPA is genotoxic. We studied the initiating activity of CPA in vivo by means of a rat liver foci bioassay, using weanling female Sprague-Dawley rats. The results show that CPA induces adenosine-triphosphatase-deficient and γ-glutamyltranspeptidase-positive putative preneoplastic foci in a dose-dependent manner. This indicates that CPA has not only promoting but also initiating activity and may therefore act as a complete carcinogen in rat liver.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0143-3334
e-ISSN
1460-2180
Journal
Carcinogenesis
Quellenangaben
Volume: 14,
Issue: 6,
Pages: 1229-1231
Publisher
Oxford University Press
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie