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Maier, J. ; Schott, K. ; Werner, T. ; Bacher, A. ; Ziegler, I.

Northern blot analysis of sepiapterin reductase mRNA in mammalian cell lines and tissues.

Adv. Exp. Med. Biol. 338, 195-198 (1993)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Recent evidence has shown that H4biopterin is synthesized in cells which undergo cytokine-directed proliferation and do not use H4biopterin as a hydroxylation cofactor. H4biopterin, in turn, enhances the proliferation of erythroleukemic cells and modulates various aspects of the interleukin-2-induced clonal expansion of T cells.1 In these cells the activity of sepiapterin reductase (SR) is in the range of 100 pmol min-1 mg-1.Lectin Stimulation of resting T cells causes a slowly progressing increase, starting from levels below detection and a transient enhancement of SR activity is found after treatment of activated T cells by interferon-γ plus interleukin-2.1 The NK-like human cell line YT and the murine erythroleukemic cell line B8/3 lack any SR activity. The molecular basis of SR regulation has not been explained in any of these cases.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0065-2598
Journal Advances in Experimental Medicine and Biology
Quellenangaben Volume: 338, Issue: , Pages: 195-198 Article Number: , Supplement: ,
Publisher Springer
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)