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Open Access Green as soon as Postprint is submitted to ZB.
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Carcinogenesis 14, 2127-2129 (1993)
Gap junctional intercellular communication (IC) was studied in γ-glutamyltranspeptidase (γ-GT)-positive and -negative hepatocytes isolated from carcinogen-treated rats. Putative preneoplastic γ-GT-positive hepatocytes were visualized in monolayer cultures by indirect immunofluorescence using anti-γ-GT-antibodies. IC was evaluated by studying dye coupling of the cells. γ-GT-positive hepatocytes showed a significantly lower dye coupling than did γ-GT-negative liver cells. Spread of the dye Lucifer Yellow CH to neighboring cells was decreased further by the tumor-promoting chemical phenobarbital in both cell types in vitro. Also treatment in vivo with the barbiturate significantly reduced dye coupling of hepatocytes. The findings suggest that as a result of their decreased ability to communicate, preneoplastic hepatocytes may escape from growth control and differentiation signals given out by surrounding 'normal' cells.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0143-3334
e-ISSN
1460-2180
Journal
Carcinogenesis
Quellenangaben
Volume: 14,
Issue: 10,
Pages: 2127-2129
Publisher
Oxford University Press
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie