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Open Access Green as soon as Postprint is submitted to ZB.
On the cytotoxicity of irradiated media. To what extent are stable products of radical chain reactions in physiological saline responsible for cell death?.
Int. J. Radiat. Biol. 64, 311-318 (1993)
In a previous publication (Czapski et al. 1992) we reported that HOCl accounts for the toxicity of irradiated phosphate-buffered saline towards Escherichia coli bacterial cells. We have now investigated the respective toxicities towards λ phage and mammalian cells. For phage, as with bacteria, cytotoxicity of the irradiated media seems to derive from HOCl without detectable contribution of H2O2. Mammalian cells (V79 CHO), in contrast, are more sensitive to H2O2 than to HOCl. Both agents, however, are not able to account quantitatively for the toxicity of irradiated solutions towards V79 cells; a hitherto unidentified chlorine/oxygen derivative-being formed in the sub-micromolar concentration range-is suggested to be responsible for toxicity in the case of eukaryotes.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0955-3002
e-ISSN
1362-3095
Quellenangaben
Volume: 64,
Issue: 3,
Pages: 311-318
Publisher
Informa Healthcare
Non-patent literature
Publications
Reviewing status
Peer reviewed