PuSH - Publication Server of Helmholtz Zentrum München: Radical intermediates during the oxidation of nitropropanes. The formation of NO<sub>2</sub> from 2-nitropropane, its reactivity with nucleosides, and implications for the genotoxicity of 2-nitropropane.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Bors, W. ; Michel, C. ; Dalke, C. ; Stettmaier, K. ; Saran, M. ; Andrae, U.

Radical intermediates during the oxidation of nitropropanes. The formation of NO₂ from 2-nitropropane, its reactivity with nucleosides, and implications for the genotoxicity of 2-nitropropane.

Chem. Res. Toxicol. 6, 302-309 (1993)

DOI

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

The chemistry of the nonenzymatic oxidation of the rat liver carcinogen, 2-nitropropane, and its anionic form, propane-2-nitronate, was investigated using pulse radiolysis and EPR/spin trapping with 3,5-dibromo-4-nitrosobenzenesulfonic acid as the trapping agent. The results suggest that, following initial oxidation to a secondary alkyl radical, propane-2-nitronate is effectively degraded in a peroxidative chain reaction with the intermediary formation of peroxyl and NO2.radicals. The latter radical was shown to react appreciably fast with ribonucleosides, deoxyribonucleosides, and guanosine nucleotides. It is proposed that nonenzymatic formation of NO2.radicals after enzymatic oxidation of propane-2-nitronate to the corresponding secondary alkyl radical accounts for the induction of DNA damage observed after exposure of rats to 2-nitropropane.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

0.000

PuSH - Publication Server of Helmholtz Zentrum München

Radical intermediates during the oxidation of nitropropanes. The formation of NO2 from 2-nitropropane, its reactivity with nucleosides, and implications for the genotoxicity of 2-nitropropane.

Radical intermediates during the oxidation of nitropropanes. The formation of NO₂ from 2-nitropropane, its reactivity with nucleosides, and implications for the genotoxicity of 2-nitropropane.