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Open Access Green as soon as Postprint is submitted to ZB.
Induction of lipid-protein mismatch by xenobiotics with general membrane targets.
Biochim. Biophys. Acta-Biomembr. 1150, 130-133 (1993)
Many membrane-active xenobiotics, such as organic solvents or general anesthetics, are without specific target sites. A common, but as yet ill-defined physical mechanism of action is usually assumed. Displacement of 'boundary' lipid activators from functional membrane proteins by the induction of lipid/protein mismatch is now established as a candidate common physical mechanism. Multiple binding site kinetics demonstrate that xenobiotics can be strongly inhibitory at realistic membrane concentrations of below 4 mol%. A general equation for inhibition is derived.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Boundary Lipid ; General Anesthetic ; Kinetics ; Membrane Active Compound ; Multiple Binding Site Kinetics ; Xenobiotic
ISSN (print) / ISBN
0005-2736
e-ISSN
1879-2642
Quellenangaben
Volume: 1150,
Issue: 2,
Pages: 130-133
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biochemical Plant Pathology (BIOP)