PuSH - Publication Server of Helmholtz Zentrum München: DNase activity in murine lenses: Implications for cataractogenesis.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Graw, J. ; Liebstein, A.

DNase activity in murine lenses: Implications for cataractogenesis.

Graefes Arch. Clin. Exp. Ophthalmol. 231, 354-358 (1993)

DOI

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

In murine lens extracts a Mg2+-dependent DNase activity was found and characterized with respect to its ionic conditions. The lenticular DNase can be clearly distinguished from DNaseII. Only a moderate DNase activity is detectable in intact nuclei of lens cells from l-day-old mice, but DNase is obviously present with high activity in lens cell nuclei from 7-day-old mice. During this time, when murine eyes are not yet open, and the fiber cell nuclei including the nuclear membrane remain to be completely digested, only weak activity can be detected in cytosolic lens extracts. In three allelic dominant mice mutants exhibiting hereditary cataracts the DNase activity is inhibited. The decrease of DNase activity follows the same directionality (Cat-2(ns) > Cat-2(no) > Cat-2(t)) as the decrease in the relative content of water soluble lens proteins, which might be used as a rough indicator for the severity of cataractogenesis. Both trends are highly significant (P < 0.0001).

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

0.000