PuSH - Publication Server of Helmholtz Zentrum München: A review of the relationship between acute toxicity (LC<sub>50</sub>) of γ-hexachlorocyclohexane (γ-HCH, Lindane) and total lipid content of different fish species.

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Geyer, H.J. ; Steinberg, C.E.W. ; Scheunert, I. ; Brüggemann, R. ; Schütz, W.* ; Kettrup, A. ; Rozman, K.K.

A review of the relationship between acute toxicity (LC₅₀) of γ-hexachlorocyclohexane (γ-HCH, Lindane) and total lipid content of different fish species.

Toxicology 83, 169-179 (1993)

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Open Access Green as soon as Postprint is submitted to ZB.

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This paper provides an explanation for a 40-fold difference in the acute toxicity (LC50) of γ-hexachlorocyclohexane (γ-HCH, Lindane) in 14 different fish species, based on well recognized principles of toxicokinetics and toxicodynamics in combination with a compilation of data from the literature and some original data. The 48-h median lethal concentration (48-h LC50) of γ-HCH in 14 fish species, belonging to 6 families, range from 22 to 900 μg/l. A significant positive linear relationship was found between lipid content (% of wet weight) and the 48-h LC50 of γ-HCH in these fish species, revealing that the toxicity of γ-HCH in various fish species in decreasing with increasing total lipid content. If median lethal concentrations are normalized for 1% lipid content, then the range of 48-h LC50s is reduced to between 18 and 32 μg/l. It is concluded that lipids of aquatic organisms can serve (among other functions) as a protective storage site against the toxic effects of γ-HCH and, possibly, of other lipophilic, persistent organic chemicals which are bioconcentrated in body lipids. Therefore, in organisms with higher lipid content, a smaller fraction of a lipophilic chemical will reach target organs (liver, lung, central and peripheral nerves, etc.) to cause adverse effects. Results suggest that this correlation can be used to extrapolate the acute toxicity (48-h LC50) of γ-HCH to other fish species if their lipid content is known. Furthermore, the data generated by extrapolation of this correlation could be useful in the environmental risk assessment of freshwater and marine organisms.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords γ-hch ; γ-hexachlorocyclohexane ; Acute Toxicity ; Fish Species Differences ; Lindane ; Lipid Content

ISSN (print) / ISBN 0300-483X

e-ISSN 0300-483X

Journal Toxicology

Quellenangaben Volume: 83, Issue: 1-3, Pages: 169-179

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Ecological Chemistry (IOEC)

PuSH - Publication Server of Helmholtz Zentrum München

A review of the relationship between acute toxicity (LC50) of γ-hexachlorocyclohexane (γ-HCH, Lindane) and total lipid content of different fish species.

A review of the relationship between acute toxicity (LC₅₀) of γ-hexachlorocyclohexane (γ-HCH, Lindane) and total lipid content of different fish species.