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The recovery of 1μm aerosol particles from large human airways.

J. Aerosol Sci. 23, 477-481 (1992)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Aerosol particles with aerodynamic diameters (dac) of about 1.1 μm were inspired into human conducting airways by the bolus inhalation technique. Inhaling small volumes of aerosols ("20 cm3 - boluses") at the very end of a clean air inhalation these particles should only reach conducting human airways. Particle recoveries (RC) in the exhaled air after various periods of breath holding (tb) were measured in front of the mouth with an aerosol laser photometer. Assuming that losses of the inhaled particles were caused by sedimentation during breath holding periods, the slope of the recovery function (RC(tb)) is a measure of the airway dimensions where the particles were located at end inhalation. This function can be estimated theoretically. By comparing bolus recovery data to model calculations, assuming different aerosol distributions in airway models, and both still and stirred settling, it could be shown that aerosol boluses inhaled to lung depths < 40 cm3 do not reach alveolar airspaces during inhalation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Aerosol Inhalation ; Bolus Technique ; Deposition In Conducting Airways ; Human Lungs ; Model Calculations ; Particle Deposition ; Recovery ; Tracheobronchial Deposition
Language english
Publication Year 1992
HGF-reported in Year 0
ISSN (print) / ISBN 0021-8502
e-ISSN 1879-1964
Quellenangaben Volume: 23, Issue: Suppl. 1, Pages: 477-481 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Departments & Institutes
Scopus ID 0026977988
Erfassungsdatum 1992-12-31